Edith Swinebourne leads the Blighters on the Thames in Assassin's Creed Syndicate and is the boss of Gang War: The Thames. She fights only when drugged into a frenzy, which makes her unusually hard to put down.
Even in a berserk state Swinebourne is no match for the twins, who kill her and free the Thames from Templar control.
The Thames has no Blighter strongholds or child-labour factories, so softening up Swinebourne's territory is all about people. The Templar targets are Captain Hargrave II (Samuel Hargrave, hired to patrol the river and blamed for many bodies on its bed), the Jekyll brothers and Tom Eccleston. The bounty targets are Emmet Sedgwick, Simon Chase and George Scrivens. Henry Green is the one who asks the twins to deal with Hargrave, and they drop his body into the river.
Swinebourne lets her Blighters take the first hits and joins after some of them are down, barging through and yelling at everyone to get out of her way. She only fights while drugged, and that habit has earned her a name for being almost impossible to stop.
Bloody Nora
Bloody Nora is the Blighter leader of the City of London in Assassin's Creed Syndicate and the boss you face in Gang War: City of London. Her nickname comes from the ruthless violence that won her a place in the gang.
Cletus Strain
Cletus Strain runs the Blighters in Lambeth for Crawford Starrick and is the leader you fight in Gang War: Lambeth in Assassin's Creed Syndicate. He has a taste for theatrics and likes to smother enemies in smoke.
Crawford Starrick
Crawford Starrick is the main antagonist of Assassin's Creed Syndicate: Grand Master of the British Templars and the industrialist who controls London in 1868 through his factories, railways, banks, the Blighters gang and a ring of Templar lieutenants. Every major target the Frye twins kill is one of his people, and the main story builds toward a final confrontation with him at Buckingham Palace.
David Brewster
Sir David Brewster is the Scottish scientist and Templar experimenting on an Apple of Eden in a hidden laboratory under a Croydon train yard. He is Evie Frye's first target in Assassin's Creed Syndicate, in the memory A Simple Plan, whose optional objectives include air assassinating him.