Mary Anne Disraeli is the outspoken wife of the Prime Minister. In Driving Mrs. Disraeli she makes Jacob take her slumming in the Devil's Acre, and in return tells him who the mysterious B behind the plot against her husband is.
Jacob meets her at Downing Street, shakes off scandal-hunting reporters and shows her round the slum, trying and failing to keep the rougher sights from her. She tries her first pint at a pub and dislikes it. When a thief grabs her handbag with Desmond inside, Jacob chases him and comes back to find her deep in conversation with the Blighter John the Tosser.
Pleased with her outing, she tells Jacob that B is James Brudenell, the Earl of Cardigan, whose endless army stories she cannot stand, and promises to put in a word with her husband.
She helps plan the theft of the Gladstones' invitations. At the palace she catches Evie leaving the upper floors and insists on introducing her to Queen Victoria.
A Night to RememberA Night to Remember is the final main memory: the twins enter the Queen's ball at Buckingham Palace, Evie retrieves the vault plans from the White Drawing Room while Jacob rescues captive Royal Guards on the roofs, and both face Crawford Starrick in the vault below.Benjamin Disraeli
Benjamin Disraeli is the Prime Minister the Templars want dead in Sequence 7. Jacob poses as his bodyguard to save him, and the Disraelis later help the twins steal the Gladstones' invitations to the Buckingham Palace ball.
Earl of Cardigan
The Earl of Cardigan, James Brudenell, is the Templar politician behind the plot to kill Prime Minister Benjamin Disraeli in Sequence 7 of Assassin's Creed Syndicate. Known in Templar letters only as B, he is the target of the memory Motion to Impeach at the Palace of Westminster.
Crawford Starrick
Crawford Starrick is the main antagonist of Assassin's Creed Syndicate: Grand Master of the British Templars and the industrialist who controls London in 1868 through his factories, railways, banks, the Blighters gang and a ring of Templar lieutenants. Every major target the Frye twins kill is one of his people, and the main story builds toward a final confrontation with him at Buckingham Palace.
Evie Frye
Evie Frye is the second playable Assassin in Assassin's Creed Syndicate and the planner of the Frye twins. While Jacob tears down Starrick's businesses, her memories follow the hunt for a Shroud of Eden across London and her rivalry with the Templar occultist Lucy Thorne. She is also the playable lead of the 1888 Jack the Ripper story.