Sequence 5 is about who controls London's transport: Jacob partners with omnibus owner Pearl Attaway against Starrick's Millner Company, while Evie follows Kenway's clues to the key of the Shroud's vault. Seven memories, and completing them unlocks The Perils of Business achievement.
Henry reports that Starrick has added an omnibus firm to his railways. Jacob burns Millner's buses, steals his combustion engines with Ned Wynert's help and goes after Millner on the Thames. Evie climbs the Monument and St Paul's to find the vault key, then helps Nightingale treat Lambeth after the asylum closes. Bell joins the twins to sabotage Starrick's telegraph transmitter.
1. A Room with a View. 2. Friendly Competition. 3. Breaking News. 4. The Lady with the Lamp. 5. Research and Development. 6. Survival of the Fittest. 7. End of the Line.
Lucy Thorne takes the vault key from Evie at St Paul's. Millner's dying words lead Jacob to overhear Attaway with Starrick: she is his cousin and a Templar, and she used Jacob to clear a rival. Jacob kills her at Waterloo station and sends the engines to Charing Cross, and a grieving Starrick orders more Templars onto the streets.
Locations include the Monument to the Great Fire and St Paul's Cathedral, Lambeth Asylum, the Thames docks and Waterloo station, with the engines finally delivered to Charing Cross.
A Room with a ViewA Room with a View follows the Kenway clues to the Monument to the Great Fire and then the dome of St Paul's Cathedral, where Evie solves a disc mechanism to find the key to the Shroud's vault. Lucy Thorne is waiting, and the memory ends in a fight with her.
End of the LineEnd of the Line ends Sequence 5 at Waterloo station, where Jacob has to reach Pearl Attaway's fortified train carriage before Starrick's men collect the engines. You free a hostage station chief, clear the crowd and find a weak point in the carriage roof.Charles Darwin's London Stories
Charles Darwin's London Stories are side memories in which the naturalist, a friend of the twins since the Starrick's Soothing Syrup affair, asks for help as his enemies turn from argument to threats. You protect a fossil, destroy toxic flowers, tear down smear posters and finally rescue Darwin himself.
Charles Dickens's London Stories
Charles Dickens's London Stories are a set of side memories in which the novelist recruits Jacob and Evie Frye into the Ghost Club and sends them after rumours of demons, hauntings and spectral thieves around London. Most cases end with a human culprit behind the supposed ghost.
Epilogue
The Epilogue in Assassin's Creed Syndicate's memory list holds one memory, Pressed Flowers, where Evie collects flowers around London for Henry Green's herbarium. Collecting every pressed flower is also tied to the Language of Flowers achievement.
Karl Marx's London Stories
Karl Marx's London Stories are five side memories in which the exiled philosopher asks the Frye twins to help London's working people rather than the comfortable citizens they have already helped. You shield his union meetings from police spies, expose a dangerous factory, stop a grieving worker's bomb plot and guard a rally.