85 characters in Assassin's Creed Syndicate.
| Name | Role | Affiliation | Status |
|---|---|---|---|
| Crawford Starrick | Antagonist | Templars | |
| David Brewster | Antagonist | Templars | |
| David Roaming | Minor | Jack the Ripper | |
| Duleep Singh | Supporting | — | |
| Earl of Cardigan | Antagonist | Templars | |
| Edith Swinebourne | Antagonist | Templars, Blighters | |
| Edward Bayley | Minor | — | |
| Elizabeth Stride | Minor | Assassins | |
| Elizabeth Stride | Minor | — | |
| Ethan Frye | Minor | Assassins | |
| Evie Frye | Protagonist | Assassins | |
| Florence Nightingale | Supporting | — | |
| Frederick Abberline | Supporting | Metropolitan Police | |
| Galina Voronina | Supporting | Assassins | |
| George Westhouse | Supporting | Assassins | |
| Henry Green | Companion | Assassins | |
| Henry Raymond | Supporting | — | |
| Isabelle Ardant | Supporting | Templars | |
| Jack the Ripper | Antagonist | Rooks | |
 Jacob Frye | Protagonist | Assassins | |
| John Billingsworth | Antagonist | Jack the Ripper | |
| John Elliotson | Antagonist | Templars | |
| John the Tosser | Minor | Blighters | |
| Juhani Otso Berg | Supporting | Templars |