Boston, Massachusetts is the first region after the time skip and the city where Ellie grew up. You play The Quarantine Zone and The Outskirts here, and Left Behind's flashbacks with Riley take place in the same city. FEDRA holds the North End as one of the last working quarantine zones in the country.
Rations are handed out against ration cards, with half-ration weeks when supplies run short. Adults can be drafted into work details, and soldiers scan people for infection and shoot anyone who tests positive. Captured Fireflies are executed in public. Joel and Tess run much of the smuggling in and out of the city from an apartment in the upper areas.
The upper areas, numbered 1, 3 and 4 on military maps, hold the checkpoints, apartments and ration lines. Area 5, the slums, sits away from most patrols and has a wharf, a warehouse and the black market, where people bet ration cards on fights and poker. Tunnels under some buildings let smugglers slip past the wall.
Downtown Boston was bombed early in the outbreak and is now overrun. Marlene hires Joel and Tess to walk Ellie across it to a Firefly group waiting at the Capitol Building, in exchange for the weapons Robert sold to the Fireflies.
The Quarantine ZoneThe Quarantine Zone starts the story proper 20 years after the outbreak, inside Boston's military-run zone in August 2033. As Joel, now a smuggler, you and his partner Tess slip outside the wall to track down Robert, a dealer who owes them guns, and end up taking a new job from the Fireflies.Pittsburgh
Pittsburgh, Pennsylvania is a former quarantine zone now run by hunters who ambush anyone passing through. Joel and Ellie spend two chapters here, Pittsburgh and The Suburbs, and meet the brothers Henry and Sam. Expect heavy human combat and the largest pile of collectibles in the game.
Lincoln
Lincoln is a small Massachusetts town a few miles from Boston and the setting of Bill's Town, the fourth chapter. Joel and Ellie come here to call in a favor from Bill, a paranoid survivor who has rigged the whole town with traps, because they need a working vehicle.
Salt Lake City
Salt Lake City, Utah is the last stop on Joel and Ellie's search for the Fireflies. It is an abandoned quarantine zone where the Fireflies hold Saint Mary's Hospital, and you play the Bus Depot and The Firefly Lab chapters here in spring 2034.
Boulder
Boulder, Colorado is where Joel and Ellie search the University of Eastern Colorado for the Fireflies in The University chapter. Left Behind's present-day story picks up nearby at the Colorado Mountain Plaza mall, so this region covers both the campus and the mall.