Salt Lake City, Utah is the last stop on Joel and Ellie's search for the Fireflies. It is an abandoned quarantine zone where the Fireflies hold Saint Mary's Hospital, and you play the Bus Depot and The Firefly Lab chapters here in spring 2034.
You pass a highway of wrecked cars, the empty QZ and its medical triage tents, and the bus station where Ellie finds the giraffes. Joel offers to turn back for Jackson, and Ellie refuses. You then cross an underground tunnel full of infected on the way to the hospital.
The military built a walled QZ here with checkpoints, a triage center, a hospital and a bus depot, then abandoned it for unknown reasons. The Fireflies never cleared the whole city, only the hospital and its surroundings.
Joel wakes in a Firefly hospital bed and learns the surgery to make a vaccine would kill Ellie. He fights through the hospital, kills Marlene and drives away with Ellie.
Bus DepotBus Depot opens in the spring of 2034 as Joel and Ellie walk into Salt Lake City, aiming for the Fireflies at Saint Mary's Hospital. The route runs along a highway full of dead cars, through the Logan James bus station and an abandoned quarantine zone, and down into a flooded tunnel full of infected.
BloaterBloaters are stage four infected covered in armor-like fungus. They are slow and blind but kill you instantly if they grab you, and they throw bursting sacks of mycotoxin from range. Fire is the way to beat them.Boston
Boston, Massachusetts is the first region after the time skip and the city where Ellie grew up. You play The Quarantine Zone and The Outskirts here, and Left Behind's flashbacks with Riley take place in the same city. FEDRA holds the North End as one of the last working quarantine zones in the country.
Pittsburgh
Pittsburgh, Pennsylvania is a former quarantine zone now run by hunters who ambush anyone passing through. Joel and Ellie spend two chapters here, Pittsburgh and The Suburbs, and meet the brothers Henry and Sam. Expect heavy human combat and the largest pile of collectibles in the game.
Lincoln
Lincoln is a small Massachusetts town a few miles from Boston and the setting of Bill's Town, the fourth chapter. Joel and Ellie come here to call in a favor from Bill, a paranoid survivor who has rigged the whole town with traps, because they need a working vehicle.
Boulder
Boulder, Colorado is where Joel and Ellie search the University of Eastern Colorado for the Fireflies in The University chapter. Left Behind's present-day story picks up nearby at the Colorado Mountain Plaza mall, so this region covers both the campus and the mall.